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MALONIC AND ACETOACETIC ESTER SYNTHESIS PDF

Malonic Ester Synthesis · Synthesis of ketones. Acetoacetic Ester Synthesis β- Keto esters tend to decarboxylate after hydrolysation to β-keto carboxylic acid. Malonic Ester Synthesis. acetoacetic ester synthesis. Reaction type:Nucleophilic substitution, then ester hydrolysis and finally decarboxylation (!). Summary. Acetoacetic ester synthesis is a chemical reaction where ethyl acetoacetate is alkylated at the α-carbon to both carbonyl groups and then converted into a ketone, or more specifically an α-substituted acetone. This is very similar to malonic ester synthesis. Author: Takasa […]

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